Endocrine Abstracts

Objective: Zinc-α2 glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. We analyze ZAG expression levels in adipose tissue from a group of morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR).Design: mRNA expression levels of PPARgamma, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VA...

Objective: To compare the effects of a classic therapy to those of a novel treatment for androgen excess in adolescent girls.Study design: Randomized, open-labeled trial over 12 months.Study participants: Adolescents (n=34; mean age 16 year, BMI 23 kg/m2) with hyperinsulinemic androgen excess and without risk of pregnancy.Interventions: Ethinyl estradiol-cyproterone acetate (EE-CA; Diane 35 ...